|
KMID : 0367320070180020154
|
|
Journal of the Korean Academy of Child and Adolescent Psychiatry
2007 Volume.18 No. 2 p.154 ~ p.161
|
|
|
No Association of DRD4 Exon III Polymorphism with Attention-Deficit Hyperactivity Disorder in Korean Children Population
|
|
Cho Soo-Churl
Park Tae-Won
Kim Jae-Won
Yoo Hee-Jeong
Kim Bung-Nyun
Shin Min-Sup
Hwang Jun-Won
|
|
|
Abstract
|
|
|
Objectives:The aim of the current study is to test for the association of DRD4 exon III VNTR polymorphism with attention-deficit hyperactivity disorder(ADHD) in Korean children population.
Methods:113 Korean children with ADHD, 102 parents, and 133 control subjects participated with the current study. The distribution of genotypes and alleles of DRD4 exon III VNTR in children with ADHD was compared with that in control subjects. In addition, 69 children with ADHD and their parents were analyzed using the transmission disequilibrium test(TDT).
Results:We could not find any significant differences in the distribution of genotypes and alleles at DRD4 exon III VNTR polymorphism between children with ADHD and control subjects. In addition, there was no preferential transmission of long allele of DRD4 exon III VNTR polymorphism.
Conclusion:These results suggest that DRD4 is not associated with ADHD in Korean children population.
|
|
|
KEYWORD
|
|
|
Attention-Deficit Hyperactivity Disorder, DRD4, Genetic Association Study
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|